The word cantankerous is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Plays In The Letters cantankerous
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Seven Letter Word Alert: (88 words)
acaters, acerous, acuates, arctans, arcuate, atoners, aurates, autocar, cankers, canoers, canters, cantons, cantors, carouse, cartons, cauters, centaur, coakers, coarsen, coaster, conkers, consent, corneas, cornets, counter, cratons, cuatros, curates, enactor, encrust, korunas, nascent, natures, nectars, nektons, neurons, neutron, nonarts, noncute, nonuser, nuances, nutcake, nutcase, oatcake, octanes, outearn, outrace, outrank, rackets, rankest, ransack, recants, reckons, recoats, recount, reknots, restack, restock, restuck, retacks, rockets, rosacea, saunter, scanner, scanter, scouter, senator, stacker, stocker, stunner, tackers, tankers, tanners, tonsure, toucans, trances, treason, trounce, tuckers, uncarts, uncorks, uncrate, unearnt, unknots, unstack, unstock, untrack, urostea