The word sesquipedalian is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 30
Highest Scoring Words With Friends™ Play In The Letters sesquipedalian
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Seven Letter Word Alert: (87 words)
aediles, aidless, aliased, aliases, alpeens, alpines, anapsid, anilide, aniseed, dailies, daisies, dalasis, denials, deplane, despise, dialups, diesels, disease, dispels, dualise, elapsed, elapses, eleidin, endless, enseals, equaled, equines, eupneas, insides, inulase, islands, liaised, liaises, lineups, linseed, lipases, liquids, lupines, napless, paenula, palsied, palsies, paneled, pansies, pasquil, pasquin, penises, pieless, pinless, plaques, pleased, pleases, plussed, punless, quailed, quinide, salines, sandals, seaside, sensual, sepaled, sequela, sequels, sequins, silanes, siliqua, silique, snailed, spaniel, spelean, spinals, spindle, spinels, spinule, spleens, splined, splines, squalid, squeals, sundaes, sundial, suspend, unideal, unipeds, unseals, uplands, upsides