The word cholelithiasis is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (80 words)
achiest, aitches, alecost, alethic, aloetic, ascites, ashiest, callose, castile, castles, cellist, celosia, chaises, chalets, chaoses, chilies, chisels, cholate, ciliate, clashes, closest, closets, clothes, coalise, coalite, colitis, collate, collies, coltish, cosiest, elastic, elicits, ethical, halites, hatches, hatless, healths, helical, hellcat, hellish, hitches, holiest, hollies, hostels, hostile, ileitis, illicit, illites, illitic, iolites, ischial, isohels, isolate, italics, laciest, lactose, laicise, latches, liaises, loathes, locales, locates, oecists, oiliest, ossicle, sachets, satchel, scathes, scillas, shallot, sheaths, shellac, silicas, silicle, socials, solaces, solicit, stoical, tallies, tallish