The word tenaciousness is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 19
Highest Scoring Words With Friends™ Play In The Letters tenaciousness
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Seven Letter Word Alert: (93 words)
acetone, aconite, actions, ancient, anoints, ascents, ascites, assents, atonics, auction, aunties, caisson, canines, canteen, cantons, caseins, casinos, cassons, catenin, cations, caution, cenotes, cession, coesite, consent, consist, contain, cosiest, cosines, cousins, cuneate, easiest, encases, ensuite, entices, incants, incense, incests, insects, intense, intones, nascent, nations, neatens, neonate, noncute, nonsuit, noseans, nosiest, notices, nuances, nutcase, octanes, octenes, oecists, oneness, osseins, outsees, sanctus, sateens, seances, seasons, secants, section, seitans, seitens, senates, sensate, session, sestina, sestine, siennas, siestas, sinuate, sinuses, sonnets, stances, stannic, stenose, suction, sunnies, sunsets, suntans, sustain, tension, tissues, tocsins, toucans, unction, uneaten, unseats, unstain, unstoic