The word reprehensively is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (58 words)
elevens, enviers, helpers, inverse, leerier, nervier, peelers, peevers, peevish, pensive, phenyls, phrensy, preener, reelers, reheels, rehires, reliers, relieve, relines, relives, renerve, repeels, repiles, repiner, repines, replier, replies, reprise, rerinse, reserve, reshine, respire, reveler, revelry, reveres, reverie, reverse, reviler, reviles, reviser, seepier, serener, servile, severer, sheerer, sheerly, shelver, shivery, shrivel, silvery, sleeper, sneerer, sylvine, veilers, veneers, versine, yeelins, yelpers