The word astronomies is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 15
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (98 words)
animose, anomers, antsier, artsmen, atomise, atoners, emotion, enamors, erosion, inmates, inseams, inserts, instars, ionomer, isomers, maestro, marines, maroons, martens, martins, masters, matrons, mentors, meronts, minaret, minters, misseat, missort, misters, mitoses, moaners, moisten, moister, monitor, monster, moraine, mortise, mossier, motions, nastier, noisome, noosers, norites, nosiest, oarsmen, oration, orients, osteoma, osteons, otarine, raiment, ransoms, rations, reasons, remains, remints, restain, retains, retinas, romaine, rosiest, satires, seamost, searoom, seitans, seminar, senator, seniors, sermons, sestina, sinters, sirname, smarten, smartie, smiters, somites, somonis, sooners, soonest, sootier, sorties, stainer, stamens, stomies, stoners, stonier, stories, strains, streams, stroams, tearoom, tensors, tonearm, toonies, torsion, treason, triones, tsarism