The word emphysematous is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (29 words)
amputee, apthous, autopsy, empathy, empyema, eophyte, espouse, eustasy, eyeshot, eyespot, heptose, mashups, outsees, passout, payouts, poetess, pomatum, seamost, septums, shuteye, smashup, sophtas, stepmom, summate, symptom, teashop, thymoma, toupees, upshots