The word psychoactive is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 29
Highest Scoring Words With Friends™ Plays In The Letters psychoactive
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Seven Letter Word Alert: (47 words)
accepts, accites, achiest, actives, aitches, apocyte, ascetic, aseptic, cachets, cacoepy, captive, catches, chaotic, cheapos, chipset, choices, coaches, copycat, copyist, cotypes, ectopia, ectopic, haptics, hepatic, hospice, icecaps, isohyet, isopach, isotype, octaves, opacity, opiates, ovicyst, patches, pitches, poaches, poetics, potiche, psychic, sceptic, scythic, society, spicate, teashop, toecaps, yachtie, yeshiva