The word lopsidedness is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 19
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (57 words)
denoise, depends, deponed, depones, deposed, deposes, depside, despise, despoil, despond, diesels, dildoes, dipoles, dispels, dispend, dispose, eloined, endless, episode, epsilon, indoles, insoles, lesions, lessens, lessons, linseed, lioness, oddness, oilseed, oldness, osseins, peddles, penises, peonies, piddles, pieless, pinless, pleions, poesies, seedpod, sessile, session, sinless, soddens, soddies, sodless, soliped, sonless, spindle, spinels, spinode, spinose, spleens, splined, splines, spoiled, spondee