The word grandnephews is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 25
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (65 words)
adheres, angered, arsheen, ashweed, dangers, derange, endears, engrasp, enraged, enrages, ensnare, enwraps, ganders, gardens, gawpers, genders, gnashed, gnasher, gnawers, graphed, grasped, greased, grenade, hagseed, hagweed, handers, handsew, hangers, hardens, headers, heapers, hearsed, hedgers, hennaed, nephews, panders, penners, phrased, prawned, predawn, presage, prewash, ragweed, rehangs, reheaps, repaged, repages, resawed, reshape, respade, respawn, sharped, sharpen, sheared, spanned, spanner, spawned, spawner, speared, spender, sphered, wagered, wanders, wardens, whereas