The word depletions is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 16
Highest Scoring Words With Friends™ Play In The Letters depletions
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Seven Letter Word Alert: (49 words)
delints, denoise, denotes, dentils, depones, deposit, despite, despoil, destine, dipoles, dopiest, eloined, epidote, episode, epistle, epsilon, indoles, lenited, lenites, leptons, linseed, lionets, nestled, oilseed, onestep, openest, pelites, penlite, pentode, pentose, peonies, pestled, petiole, piloted, pleions, poetise, pointed, posited, poteens, soliped, spindle, spinode, splined, spoiled, spondee, stipend, tensile, topline, topside