The word defoliations is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 18
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (86 words)
adonise, anilide, anodise, dailies, daltons, defiant, delints, denials, dentals, dentils, destain, details, detains, dilates, doilies, donates, edition, elastin, elation, elision, enfolds, entails, fadeins, fainted, festoon, filiate, finales, finials, floated, foisted, folates, foliate, fondest, fondles, footsie, idolise, idolist, indites, indoles, infidel, infield, inflate, infolds, inosite, instead, iodines, iodites, iolites, ionised, isodont, isolate, leantos, liaised, liaison, lionets, lionise, loonies, lotions, nailset, noloads, noodles, oiliest, olefins, oleosin, onefold, onloads, oolites, osteoid, sainted, salient, seafood, sealion, sidelit, slanted, snailed, snooted, stained, stifled, stooled, stoolie, tailfin, talonid, tenfold, tinfoil, toenail, toonies