The word unprofitably is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 26
Highest Scoring Words With Friends™ Plays In The Letters unprofitably
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Seven Letter Word Alert: (38 words)
bailout, bairnly, bipolar, botulin, brutify, buoyant, butanol, faintly, fibular, flyboat, flytrap, frailty, frontal, libator, lubrify, notably, nuptial, orbital, outplan, outplay, outpray, painful, parboil, poultry, probity, ptyalin, puritan, purloin, rainout, topiary, toprail, torpify, trayful, tunably, unfitly, unitary, upfront, utopian