The word unaffectedness is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Play In The Letters unaffectedness
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Seven Letter Word Alert: (80 words)
affects, ascends, ascents, canteen, cuneate, deafens, deafest, decanes, decants, decease, decenes, defaces, defeats, defects, defence, defense, defunct, defuses, densest, descant, descent, destaff, destuff, detunes, ductase, educate, effaced, effaces, effects, effused, effuses, enacted, encased, encases, enfants, essence, faceted, fastens, fatness, faucets, feasted, fescues, fetuses, funfest, funnest, nascent, neatens, nuanced, nuances, nutcase, nutseed, sanctus, sateens, sauteed, scanned, scented, scuffed, seances, secants, secedes, sedates, seduces, senates, sensate, snafued, snuffed, snuffes, staffed, stances, standee, stuffed, stunned, sudates, sundaes, suntans, uncased, undents, uneaten, unsated, unseats