The word megalopolises is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Plays In The Letters megalopolises
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Seven Letter Word Alert: (53 words)
ageless, aimless, alleges, apogees, apologs, egoisms, egoless, elapses, ellipse, elogies, epilogs, episome, gallops, gapless, gemless, geomaps, glimpse, gliomas, glioses, goalies, goosies, gospels, imagoes, impales, impasse, imposes, legless, ligases, lipases, lipless, lipomas, magpies, mapless, measles, meioses, message, mileage, mispage, ooplasm, palsies, pegless, pieless, pillage, pleases, plimsol, poesies, pomelos, samples, semilog, siamese, simples, slaloms, spiegel