The word ghastliness is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 17
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (73 words)
aiglets, alights, anglist, ashiest, ashless, assents, assigns, elastin, elating, english, enlight, enlists, entails, gasless, geishas, gelatin, genials, genital, glasses, glisten, gnashes, haglets, halites, halting, hassles, hastens, hatless, healing, heating, ingests, inhales, lashing, lassies, lasting, lathing, leasing, lengths, ligases, ligates, lighten, listens, nailset, sagiest, salient, salines, salting, sashing, sassing, sealing, seating, seitans, sestina, shingle, siestas, signals, signets, silanes, silents, singles, singlet, sinless, slashes, slating, sleighs, sleight, slights, stashes, tagline, tangles, tassels, teasing, tingles, tinsels