The word esthetically is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 21
Highest Scoring Words With Friends™ Play In The Letters esthetically
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Seven Letter Word Alert: (53 words)
acetyls, achiest, aitches, alethic, atheise, atheist, athlete, castile, cattily, cellist, chalets, chattel, chelate, clayish, elastic, ethical, eyelash, eyeslit, halites, hastily, helical, helices, hellcat, hyalite, laciest, latches, latites, lattice, leaches, lithely, lychees, saltily, satchel, satiety, shellac, stately, statice, stealth, stylate, tacitly, tactile, tallest, tallies, tallish, tastily, teaches, techies, tellies, testacy, testily, thistle, thistly, yachtie