The word disjuncture is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Play In The Letters disjuncture
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Seven Letter Word Alert: (39 words)
cinders, cistern, credits, cretins, crudest, cruised, crusted, decrust, directs, discern, disject, dunites, dustier, encrust, incrust, inducer, induces, inducts, injects, injured, injures, insured, intrude, juicers, justice, nutsier, reducts, rescind, rudites, studier, sutured, tinders, uncited, uncured, uncurse, undrest, uniters, untired, untried