The word desynchronize is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 32
Highest Scoring Words With Friends™ Plays In The Letters
Seven Letter Word Alert: (79 words)
ceroids, cheerio, chinned, chrysin, cinders, codeine, coheirs, cohered, coheres, coiners, cronies, decoyer, decries, decynes, dehisce, dehorns, deicers, deniers, denizen, denoise, dezincs, dienyne, dinners, diocese, discern, dishorn, diynone, doyenne, dyneins, echoers, encoder, encodes, encored, encores, endorse, enzoned, enzones, heroics, heroine, heroins, heroise, heroize, hinders, honeyed, hosiery, incense, inchers, indorse, inshore, necrose, nordics, orchids, rechose, recodes, recoins, rehides, rehoned, rehones, rescind, reshine, reshoed, resized, rezoned, rezones, rosined, scenery, scorned, screeny, shinned, shrined, sincere, sydnone, synched, synodic, zechins, zeroise, zincode, zircons, zydecos