The word desynchronise is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Plays In The Letters desynchronise
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Seven Letter Word Alert: (96 words)
censers, censors, cerises, ceroids, cession, cheerio, chinned, chrysin, cinders, codeine, coheirs, cohered, coheres, coiners, cosines, coyness, cronies, crossed, decoyer, decries, decynes, dehisce, dehorns, deicers, deniers, denoise, desires, dienyne, dinners, diocese, discern, dishorn, diynone, dossier, doyenne, dryness, dyneins, echoers, encoder, encodes, encored, encores, endorse, heiress, herdess, heroics, heroine, heroins, heroise, hinders, honeyed, hosiers, hosiery, incense, inchers, indorse, inshore, necrose, nordics, oneness, orchids, rechose, recodes, recoins, redness, rehides, rehoned, rehones, rescind, resends, reshine, reshoed, reshoes, resides, rosined, scenery, scorned, screeds, screens, screeny, secerns, seconds, senders, seniors, sensory, shiners, shinned, shrined, shrines, sincere, sinners, soirees, sydnone, synched, syndics, synodic