The word despondencies is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (50 words)
cession, codeine, cosines, decenes, decides, decodes, deepend, deepens, denoise, depends, deponed, depones, deposed, deposes, depside, descend, deseeds, despise, despond, diocese, dispend, dispose, encoded, encodes, epicene, episode, essence, incense, nondeep, nonepic, oddness, oneness, penises, pennies, pension, peonies, pinenes, poesies, seceded, secedes, seconds, seedpod, soddens, soddies, species, speeded, spinode, spinons, spinose, spondee