The word despoilers is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 15
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (48 words)
deplore, deposer, deposes, depress, desires, despise, despoil, diesels, dipoles, dispels, dispose, dossier, eldress, elopers, episode, lispers, lossier, oilseed, periled, periods, pieless, poesies, preside, presold, pressed, redpole, reoiled, repiled, repiles, replied, replies, reposed, reposes, resides, resoils, resoled, resoles, rodless, sidlers, sliders, slopers, soirees, solders, soldier, soliped, spiders, spoiled, spoiler