The word nightshades is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 19
Highest Scoring Words With Friends™ Plays In The Letters nightshades
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Seven Letter Word Alert: (35 words)
ashiest, dashing, designs, destain, detains, digests, dissent, eighths, geishas, gnashed, gnashes, handset, hashing, hastens, heading, heating, heights, highest, ingests, instead, sagiest, sainted, sashing, seating, seitans, sestina, shading, sheaths, sighted, signets, snidest, stained, stashed, teasing, thighed