The word irrespective is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Play In The Letters irrespective
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Seven Letter Word Alert: (57 words)
creeper, crisper, eeriest, erecter, evictee, peevers, pervert, picrite, piercer, pierces, pieties, pitiers, precise, pricers, pricier, receipt, receive, recipes, reciter, recites, reerect, reprice, reprise, reserve, respect, respice, respire, respite, restive, retiree, retires, retrees, retries, reveres, reverie, reverse, reverts, reviser, revisit, riveter, scepter, sceptre, secrete, seepier, service, severer, sievert, specter, spectre, spicier, steeper, steerer, stivier, striper, striver, tipsier, triceps