The word distressfully is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Play In The Letters distressfully
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Seven Letter Word Alert: (97 words)
delists, desilts, desists, diluter, dilutes, direful, distyle, duelist, dullest, dusters, dustier, dustily, fillers, fillets, filters, firstly, fissure, fistule, flirted, fluidly, fluster, fluters, flyless, frilled, fruited, fullers, fullest, furless, fussers, fussier, fussily, futiley, issuers, lidless, lifters, listful, luridly, lusters, lustier, lustily, lyrists, refills, relists, resifts, resists, restful, restudy, results, retills, rillets, rudites, russets, rustily, rustled, rustles, rutiles, sidlers, sifters, sisters, sliders, stifled, stifler, stifles, stilled, stiller, strides, strifes, strudel, studier, studies, stylers, stylier, stylise, sudsers, sudsier, suiters, sulfide, sulfite, sullied, sullies, surfeit, surlily, sutlers, sutlery, tillers, tiredly, tissued, tissues, tissuey, trellis, trifled, trifles, trilled, trussed, trusses, tussled, tussles