The word fruitlessly is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 19
Highest Scoring Words With Friends™ Plays In The Letters fruitlessly
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Seven Letter Word Alert: (50 words)
fillers, fillets, filters, firstly, fissure, fistule, fluster, fluters, flyless, fullers, fullest, furless, fussier, fussily, futiley, lifters, listful, lusters, lustier, lustily, lyrists, refills, relists, resifts, restful, results, retills, rillets, rustily, rustles, rutiles, sifters, stifler, stifles, stiller, strifes, stylers, stylier, stylise, suiters, sulfite, sullies, surfeit, surlily, sutlers, sutlery, tillers, tissuey, trellis, trifles