The word disestablishes is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 21
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (83 words)
abseils, aediles, aidless, albites, alibies, ashiest, ashless, assists, astilbe, atheise, baldest, baldish, bassets, bassist, bedless, bedsits, beheads, belated, besides, betides, biassed, biasses, blasted, bleated, blessed, blesses, blissed, blisses, dailies, daisies, deashes, debases, debates, deities, delates, delists, desalts, desilts, desists, details, diesels, dieties, dilates, disable, disease, distils, easiest, edibles, halides, halites, hassles, hatless, headset, heisted, hessite, hissies, lassies, leadeth, leashed, leashes, liaised, liaises, libated, libates, sadists, seabeds, seaside, sedates, sessile, shields, sidelit, siestas, sissies, slashed, slashes, stabled, stables, stashed, stashes, tassels, tealess, teasels, tieless