The word defoliators is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 16
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (85 words)
aerosol, aridest, astride, astroid, defrost, delator, derails, details, dialers, dilater, dilates, dilator, disrate, disroot, editors, estriol, fairest, falters, fardels, fedoras, filters, flirted, floated, floater, flooder, floored, florets, florist, foisted, foister, folates, folders, foliate, footers, footsie, forties, frosted, isolate, leotard, lifters, loaders, loafers, loftier, loiters, looters, oolites, ordeals, orioles, osteoid, realist, redials, refloat, reflood, refolds, reloads, retails, retools, roadies, roasted, roisted, roosted, roseola, saltier, seafood, slatier, soldier, sootier, sortied, steroid, stifled, stifler, stooled, stoolie, storied, tailors, tierods, tirades, toilers, toolers, toroids, trailed, trefoil, trifled, trifles, trifold