The word colpoxerosis is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 26
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (38 words)
closers, colossi, coolers, copiers, corpses, coxless, creosol, cresols, exoloop, lispers, loopier, lossier, ooscope, oospore, orioles, ossicle, oxslips, plexors, polices, poroses, porosis, precool, process, proxies, reclips, recoils, resoils, respool, scooper, scorpio, slicers, slopers, spicers, splicer, splices, spoiler, spooler, xerosis