The word acantholysis is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 21
Highest Scoring Words With Friends™ Plays In The Letters
Seven Letter Word Alert: (37 words)
acholia, actions, acyloin, alicant, analyst, atonias, atonics, caisson, casinos, cations, clayish, coastal, coltish, consist, cyathia, cytosis, halcyon, hastily, nastily, oilcans, saintly, satanic, scantly, snatchy, snitchy, socials, sonatas, stanols, stoical, stonily, stonish, stylion, stylish, tachyon, tocsins, tonsils, tylosis