The word insolubilities is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 21
Highest Scoring Words With Friends™ Play In The Letters insolubilities
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Seven Letter Word Alert: (74 words)
betoils, billets, billion, biolite, biotins, blouses, boluses, boniest, bonuses, botulin, bullets, bullies, bullion, busiest, bustles, elision, elusion, elution, enlists, ensouls, ileitis, illites, illness, inosite, insoles, instill, insults, iolites, ionises, lentils, lesions, lintels, lioness, lionets, lionise, listens, lobules, lotuses, luniest, niobite, noblest, nosiest, oiliest, outlies, outline, outsell, sellout, silents, soluble, solutes, stollen, sublets, sublist, subnets, subnote, subsite, subslot, subsoil, subtone, sullies, sunbelt, tinsels, tonsils, tousles, tubless, unbelts, unbless, unblest, unbolts, unilobe, unities, unlists, utensil, utilise