The word grapefruits is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 20
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (60 words)
aigrets, arguers, artsier, aspirer, augites, fairest, fatigue, figurer, figures, fraters, frigate, furries, gaiters, garrets, garters, gaspier, grafter, grasper, graters, gripers, grister, guitars, gustier, gutsier, pargets, parties, pastier, pasture, pirates, praiser, praters, presift, purgers, rafters, rapture, raspier, regraft, regrasp, regrips, repairs, restrap, retraps, rugrats, rustier, spurter, stagier, stirrup, striper, sugarer, surfeit, tarries, traipse, triages, turfier, upraise, uprates, uprears, upriser, upstage, upstair