The word disencumber is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (62 words)
bemired, bemires, bemused, benders, bendier, binders, birdmen, bruised, bucines, burdens, censure, ceriums, cerumen, cinders, crubeen, cruised, crumbed, cumenes, decries, decrumb, deicers, deniers, derbies, discern, enbused, endemic, endures, ensured, erbiums, imburse, inbreds, inbreed, incubee, inducer, induces, insured, menders, mercies, mincers, minders, miscued, numbers, numeric, rebinds, recused, reduces, remends, reminds, remined, remines, rescind, rescued, residue, resumed, scribed, secured, seducer, sincere, suberin, sunbird, uncrime, unembed