The word disaffection is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (80 words)
acnodes, aconite, actions, adonise, affects, affined, affines, anodise, atonics, candies, castoff, cations, coasted, coedits, coffins, coiffed, confide, confits, conidia, dacites, deacons, decants, defiant, deficit, deistic, descant, destaff, destain, detains, diciest, diction, dietics, discant, donates, edition, eosinic, faction, fadeins, fainted, fancied, fancies, fiances, fiction, fifties, foisted, fondest, iconist, incased, incised, incited, incites, indices, indicts, indites, infects, inosite, instead, iodines, iodites, ionised, nicosia, noticed, notices, octanes, offends, offices, offside, offsite, sainted, scoffed, section, sendoff, sniffed, staffed, stained, stiffed, stiffen, tacnode, taffies, toffies