The word despitefully is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 24
Highest Scoring Words With Friends™ Plays In The Letters
Seven Letter Word Alert: (55 words)
defiles, deputes, despite, dilutes, dispell, dispute, distyle, duelist, dullest, dustily, ellipse, epistle, eustely, eustyle, eyefuls, eyelids, eyelift, eyepits, eyeslit, fellest, felsite, fileted, fillets, fillups, fistule, fleetly, fluidly, fuelled, fullest, futiley, lefties, listful, lustily, pelites, pellets, pestled, pullets, pulleys, seedily, spelled, spilled, steeply, stifled, stilled, stipule, stupefy, stupify, sulfide, sulfite, sullied, tellies, tepidly, typedef, upfills, uplifts