The word butterscotch is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 24
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (34 words)
becrust, bescour, betroth, borscht, botcher, botches, bothers, butcher, butters, cherubs, chouser, cotters, couches, crochet, cutters, herbous, hottest, hottubs, obscure, obtuser, outbets, retouch, scouter, shouter, shutter, stouter, stretch, stutter, torches, totters, toucher, touches, touters, turbots