The word affectionately is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Play In The Letters affectionately
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Seven Letter Word Alert: (58 words)
acetate, acetify, acetone, acolyte, aconite, acylate, acyloin, aeolian, affiant, affinal, afflict, alicant, aloetic, analyte, cattail, cattily, coalify, coalite, cotylae, cyanate, cyanite, elation, enocyte, enolate, entitle, eyelift, faction, faintly, falcate, fanatic, fancify, fancily, fantail, fiancee, fifteen, flatten, foliate, icefloe, inflate, inflect, inocyte, lactate, lactone, latency, lattice, lection, lineate, nattily, neocyte, nictate, offence, offline, tacitly, tactile, taffeta, tailfan, tetanic, toenail