The word optimistically is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Plays In The Letters optimistically
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Seven Letter Word Alert: (58 words)
altoist, aplitic, atomics, calypso, campily, capitol, cattily, coalpit, colitis, copyist, cystoma, cytomas, illicit, illitic, impacts, impasto, italics, lamplit, lipomas, militia, miscall, miscopy, misplay, mistily, mitotic, moistly, myotics, opacity, optical, optimal, palmist, plastic, plimsol, politic, potamic, psalmic, saltily, scallop, slimily, soapily, solicit, somatic, somitic, spicily, spotlit, stoical, styptic, tacitly, tastily, tipcats, tipmost, tipsily, tomcats, topical, topmast, topsail, totally, typical