The word misalliance is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 20
Highest Scoring Words With Friends™ Plays In The Letters misalliance
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Seven Letter Word Alert: (23 words)
aclinal, amnesia, amnesic, anaemic, animals, cinemas, encalms, icemans, lacinia, laicise, laminae, laminal, laminas, malaise, malices, manacle, maniacs, manilla, menisci, micella, miscall, seminal, silicle