The word excruciation is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Plays In The Letters excruciation
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Seven Letter Word Alert: (43 words)
account, aconite, actinic, auction, auxetic, auxinic, axinite, caution, centaur, centric, certain, circuit, citrine, cocaine, conceit, concert, cornice, counter, curtain, enactor, erotica, eutaxic, eutaxon, exactor, exciton, excitor, exotica, icteric, inciter, inertia, inexact, oceanic, otarine, outearn, outrace, rainout, recount, routine, triaxon, trounce, uncrate, urinate, xerotic