The word enucleation is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 18
Highest Scoring Words With Friends™ Play In The Letters enucleation
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Seven Letter Word Alert: (37 words)
acetone, aconite, aloetic, ancient, annulet, antlion, auction, cannoli, canteen, catenin, cauline, caution, coalite, contain, cuneate, cutline, elation, elocute, elution, enolate, lactone, lection, lenient, leucine, leucite, lineate, lunatic, neonate, noncute, nonlate, nucleon, outline, toenail, toluene, unclean, unction, uneaten