The word disaffecting is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 25
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (55 words)
affects, affined, affines, cagiest, candies, casting, ceasing, dacites, decants, defangs, defiant, deficit, deicing, deistic, descant, destaff, destain, detains, diciest, dietics, dieting, dingies, discant, editing, facings, fadeins, fainted, fancied, fancies, fasting, fiances, fidgets, fifties, ignited, ignites, incased, incised, incited, incites, indices, indicts, indites, infects, instead, sainted, seating, sifting, sniffed, staffed, stained, stiffed, stiffen, taffies, teasing, tidings