The word depressurize is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 26
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (45 words)
depress, derries, desirer, desires, despise, dresser, dressup, perused, peruses, preside, pressed, presser, pursers, pussier, redress, redries, reedier, reissue, repress, reprise, reprize, reseeds, reseize, resider, resides, residue, resized, resizes, respire, seeders, seedier, seepier, seizers, seizure, speeder, spiders, spurred, sudsier, supered, suspire, upriser, uprises, upsides, upsized, upsizes