The word depopulating is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 24
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (95 words)
agitpop, aligned, applied, appoint, dapping, dealign, dealing, dilogun, diluent, dueling, elating, elation, eloping, eluding, eluting, elution, euploid, gaunted, gelatin, genital, geoidal, glinted, gloated, gluepot, godetia, goldpan, guilted, indulge, languid, lapping, lauding, leading, leaping, ligated, loading, lopping, lounged, lunated, nepotal, nippled, notepad, nuptial, opaline, opiated, opulent, outgain, outlead, outleap, outline, outpipe, outplan, painted, patined, pealing, pelting, pentail, petunia, piloted, pingled, plagued, plaited, planted, plating, plaudit, plunged, pointed, poundal, poutine, pouting, pulping, pupated, tadpole, tagline, tailgun, talonid, tangelo, tangled, tangoed, tapping, tingled, tippled, toenail, toluide, tongued, topline, topping, toppled, unagile, undealt, unideal, unipole, unoiled, untaped, untiled, utopian