The word careerisms is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 16
Highest Scoring Words With Friends™ Plays In The Letters
Seven Letter Word Alert: (29 words)
amercer, amerces, careers, carries, cerises, crasser, creamer, creaser, creases, erasers, icemass, marries, mercers, mercies, messier, racemes, racisms, raisers, reamers, rearise, scarers, scarier, screams, seamers, seamier, seriema, siamese, sierras, smearer