The word stupendously is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Play In The Letters stupendously
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Seven Letter Word Alert: (44 words)
deploys, despots, dotless, dustups, duteous, ensouls, leptons, lotuses, loudest, lupuses, nodules, notedly, oldness, opulent, outduel, outsped, outspun, outyelp, penults, plussed, plutons, punless, pustule, snouted, solutes, soundly, spoused, spouted, stepson, stylops, sunspot, suspend, systole, tenuous, topless, tousled, tousles, toyless, tuneups, tussled, tyloses, unposed, unstops, untyped