The word saponification is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 25
Highest Scoring Words With Friends™ Play In The Letters saponification
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Seven Letter Word Alert: (41 words)
actions, anaptic, anionic, anoints, atonias, atonics, caftans, cantons, capstan, captain, caption, cations, catnaps, catnips, confits, contain, faction, fanatic, fiction, finspot, iconist, incants, infants, nations, niacins, nicosia, nonfact, nonfast, nonstop, notions, opinion, options, patinas, pianist, pinions, potions, psionic, saponin, satanic, stannic, tapioca