The word irregardless is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 16
Highest Scoring Words With Friends™ Play In The Letters irregardless
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Seven Letter Word Alert: (74 words)
aediles, ageless, aidless, airless, dealers, dearies, degases, derails, derries, desirer, desires, dialers, diesels, digress, disease, dresser, earless, earlier, eldress, erasers, gassier, gelders, gilders, girders, girdles, glassed, gliders, graders, grassed, greased, greaser, greases, lagered, larders, lardier, largess, leaders, leasers, ledgers, ligases, raiders, raisers, readers, readier, readies, realers, realise, rearise, redeals, redials, redrags, redress, redries, regards, regears, regilds, regrade, regress, reliers, rereads, resails, resales, reseals, resider, resides, sailers, sealers, seaside, sedgier, serials, sidlers, sierras, sledges, sliders