The word disquietingly is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 30
Highest Scoring Words With Friends™ Plays In The Letters
Seven Letter Word Alert: (70 words)
delints, density, dentils, destiny, dieting, dignity, diluent, dilutes, dingies, dingily, distyle, dueling, duelist, dunites, dustily, dusting, dyeings, editing, eliding, eluding, eluting, glinted, glisten, gluiest, glutens, guilted, guldens, gustily, ignited, ignites, ileitis, indites, indulge, inquest, inquiet, instyle, lignite, liquids, listing, luniest, lusting, quietly, quilted, quinide, quinsey, quiting, sidelit, sidling, silique, silting, singled, singlet, sliding, snidely, squidge, squidgy, squinty, styling, suiting, tidings, tidying, tilings, tingled, tingles, ugliest, unities, unsilty, untiled, utensil, utilise