The word depressurises is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 18
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (42 words)
depress, derries, desirer, desires, despise, dresser, dresses, dressup, issuers, perused, peruses, preside, pressed, presser, presses, pursers, pussier, pussies, redress, redries, reedier, reissue, repress, reprise, reseeds, resider, resides, residue, respire, seeders, seedier, seepier, speeder, spiders, spurred, sudsers, sudsier, supered, suspire, upriser, uprises, upsides